The not-for-profit 501(c)(3) Eye Research Foundation (ERF) at East Florida Eye Institute exemplifies our commitment to advancing the diagnosis, prevention, and treatment of eye disease through our groundbreaking research.
Dr. Frenkel's research was published in the British Journal of Ophthalmology.
Using a simple gray filter to stress patients' eyes, ophthalmologists are able to predict visual acuity change during anti-vascular endothelial growth factor A (anti-VEGF) therapy for wet age-related macular degeneration (AMD), according to a new study.
"Now we are able to tell patients with a high degree of accuracy how they will do with anti-VEGF injections," Dr. Ronald E.P. Frenkel, who led the study, told Reuters Health by phone. "The method is so elegant and it has incredible predictability. We couldn't tell patients before what to expect."
He noted that previously, the test had proved helpful in patients with dry AMD, but this is the first time anyone has tested it in patients with wet AMD.
Dr. Frenkel, of Bascom Palmer Eye Institute, Miami, and colleagues conducted the HARBOR trial, a two-year, phase 3 randomized trial of intravitreal ranibizumab (Lucentis) 0.5 or 2.0 mg monthly or as needed in wet AMD patients. A total of 1,084 patients were enrolled in the trial. Their mean age was 78.7 years and about 60 percent were women. In a Nov. 5 online paper in the British Journal of Ophthalmology, Dr. Frenkel and colleagues report change in best corrected visual acuity (BCVA) under optimal illumination over the course of the two-year study. The researchers also evaluated low-luminance visual acuity (LLVA).
Dr. Frenkel discovers a way to predict prognosis for Wet Macular Degeneration patients.
Ronald Frenkel, MD, FACS, FICS has discovered a new way to let patients with Wet Macular Degeneration know the prognosis of treatment before they start it. Dr. Frenkel has been awarded this presentation at the annual meeting of ARVO, the Association for Research in Vision and Ophthlalmology, the largest eye research meeting in the world. Dr. Frenkel served as Principal Investigator at the East Florida Eye Institute in Stuart. He headed up the portion of the colossal national multi-center HARBOR clinical trial for Wet Macular
Degeneration treatment that discovered how to predict the patient's prognosis and response to treatment, when one is first diagnosed with the disease. The study had 99 participating centers from across the United States and enrolled 1097 patients with newly diagnosed Wet Macular Degeneration. This will have a significant impact on patients and their families as such a prognosis does not currently exist.
Avoiding blood pressure dips helps prevent worsening of glaucoma
Current risk factors for glaucoma include high eye pressure, age, family history, and thin corneas. Through our research, we have discovered a new risk factor for glaucoma: nighttime dips in blood pressure. By having patients wear a blood pressure monitor for a 24-hour period, we have found that patients with worsening glaucoma despite “controlled” eye pressures have significant drops in their blood pressure at night. Decreased blood pressure causes decreased blood flow to the optic nerve, resulting in glaucomatous nerve damage. We work with patients’ medical doctors to diminish this risk so that glaucoma can be prevented or stabilized. (Presented at the Annual Meeting of the American Academy of Ophthalmology)
New combination treatment can improve vision in patients with certain retinal problems
Patients who have vision loss secondary to a lack of oxygen to the eye may get an improvement in vision from high tension oxygen treatment, given in association with laser and steroid therapy. This was demonstrated in a patient who had vision loss from radiation treatment for a brain tumor, who regained his vision after combination treatment. (Presented at the Annual Meeting of the Association for Research in Vision and Ophthalmology)
Glaucoma medication can be administered differently to decrease eye redness & improve comfort
We are currently investigating methods to reduce side effects from glaucoma drops, allowing more patients to benefit from these drugs. Patients who have been unable to tolerate the latest, most effective pressure lowering drugs often have had success with this new method that alters the dosing of the drug. (Submitted for presentation)
Eye pressure spikes which occur at night and during sleep are important to control
Doctors have long known that when a patient’s eye pressure is checked in the office it is just a sampling of the routine fluctuations that everyone has over a 24 hour period. Although eye pressure may appear controlled in the office, by measuring it around the clock, we have found that eye pressure not only increases during sleep, but also increases when patients are lying down versus when they are sitting up. This is a concern for glaucoma patients and suspects. By monitoring patients treated with different medications, we are determining which drugs are better able to treat this problem.